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Editor-in-Chief eMediNexus – Dr KK Aggarwal
5th August 2018
All about Indian tick typhus

Dr KK Aggarwal, Recipient of Padma Shri

  • Indian tick typhus is a disease of the spotted fever group of Rickettsiae caused by Rickettsia conorrii subsp indica.
  • In India, the Indian tick typhus is prevalent in hilly forest areas. Infection has been seroepidemiologically reported from various parts of the country such as Nagpur, Jabalpur, Jammu and Kashmir, Kanpur, Sagar, Pune, Lucknow, Bangalore and Kangra.
  • The brown dog tick (Rhipicephalus sanguineus is the reservoir of infection and is infective at all stages of its life. Infection in nature is maintained by transovarian and trans-stadial passage. The rickettsiae can be transmitted to dogs, rodents. Man is an accident host and acquires the infection by the bite of infected tick.
  • The incubation period is usually 3 to 7 days.
  • The patient will give a history of a recent tick bite.
  • Clinically, the infection presents as acute onset of moderate to high grade fever, which may persist for 2-3 weeks, malaise, headache, deep muscle pain. A maculopapular rash appears on the 3rd day of fever. Unlike the rash in other rickettsial diseases, in Indian tick typhus, the rash is first seen on the extremities (ankles and wrists), moves centripetally and involves the rest of the body.
  • Unlike other spotted fever group, the maculopapular rash in Indian more
Top News

Bhutan, Maldives and Timor-Leste become the 1st three countries in WHO South-East Asia to achieve both measles elimination & rubella control

In a significant win against childhood killer diseases, two countries of WHO South-East Asia Region, DPR Korea and Timor-Leste, have been verified for eliminating measles, and six countries certified for controlling rubella and congenital rubella syndrome, two years ahead of the target year 2020.... read more

Morning Medtalks

Morning MEDTalks with Dr KK Aggarwal 5th August 2018

Smoking and air pollution have similar effects Smokers and non-smokers now represent an equal number of lung cancer patients, according to a study carried out by the Lung Care Foundation. An analysis of 150 patients at Sir Ganga Ram Hospital (SGRH), New Delhi, found that about 50% of patients with lung cancer–the type of cancer responsible for the highest number of cancer deaths nationwide–had never smoked, and yet had developed the pulmonary disease. There is strong evidence that points to the role of air pollution in the ... read more

Practice Updates

Sunitinib alone not inferior to nephrectomy with sunitinib in metastatic renal-cell carcinoma

Sunitinib alone was not inferior to nephrectomy followed by sunitinib in patients with metastatic clear-cell renal-cell carcinoma who were classified as having intermediate-risk or poor-risk disease in a study published August 2, 2018 in the New England Journal of Medicine.... read more

Risankizumab enhances remission rates in moderate to severe refractory Crohn's disease

Extended treatment with 600 mg intravenous risankizumab in patients with moderate to severe, treatment-refractory Crohn's disease who were not in deep remission at week 12, increased clinical response and remission rates at week 26, as per a study published in the Lancet Gastroenterology and Hepatology. ... read more

4-month rifampin as good as standard 9-month INH in preventing active TB in latent infection

A shorter, 4-month course of rifampin was non-inferior to the standard 9-month regimen of isoniazid (INH) at preventing active tuberculosis (TB) among adults with latent TB infection and was associated with a higher rate of treatment completion and better safety, as per a study ... read more

Further lowering of LDL-C beyond lowest current targets further reduces cardiovascular risk.

Further lowering of low-density lipoprotein (LDL) cholesterol (LDL-C) levels beyond the lowest current targets is associated with reduced risk for major vascular events with no serious adverse effects, suggests a large meta-analysis published online August 1, 2018 in JAMA Cardiology.... read more

Silent myocardial impairment may be present in patients with drug-naive, new-onset SLE

New research published August 2, 2018 in the journal Arthritis & Rheumatology indicates that silent cardiac impairment may be present in new-onset, drug-naive systemic lupus erythematosus (SLE), even before any symptoms of chest discomfort. Native myocardial T1 values and ECV could serve as early detection markers of myocardial injury before the presence of visual fibrosis ... read more

eMedi Humor
Medicolegal Corner
eMedi Quiz
1. Campylobacter enteritis is an important cause of acute diarrhea
2. It is never seen in India
3. It is typically caused by Campylobacter jejuni or Campylobacter coli, and is largely a foodborne disease.
4. Campylobacter infection can also be transmitted via water-borne outbreaks and direct contact with animals or animal products.
Lifestyle Updates
Inspirational Story 1: The 12 Gifts of Birth
Inspirational Story 2: Don’t ever stop doing good
Hospital-acquired bacterial infections on the rise
All healthcare establishments should follow basic precautions and practice hand hygiene
New Delhi, 04 August 2018: As per a recent Australian study, some hospital superbugs are growing increasingly tolerant to alcohol-based disinfectants found in hand washes and sanitizers, allowing increasing infections to take hold. There has been a rise in a kind of bacteria that lives in the gut, called Enterococcus faecium which can spread via catheters, ventilators or central lines in a health care setting.Drug-resistant E. faecium infections currently represent a leading cause of infections acquired in hospitals.

Enterococci account for about 1 in 10 cases of hospital-acquired bacterial infections around the world. Research suggests that there may be something about the physiology of E. faecium that makes it easier for the bacteria to evolve tolerance to alcohol exposure.

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