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Editor-in-Chief eMediNexus – Dr KK Aggarwal
22nd November 2018
Reciprocal association between NAFLD and drug-induced liver injury
NAFLD may be a risk factor for DILI; drugs can cause NAFLD

Dr KK Aggarwal, Padma Shri Awardee

Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease globally. It is characterized by the presence of hepatic steatosis (fatty liver), when no other causes for secondary hepatic fat accumulation (heavy alcohol consumption) are present. Left untreated, it may progress to cirrhosis and is likely an important cause of cryptogenic cirrhosis.

The prevalence of this condition is higher among obese and diabetic patients. Recently NAFLD has also been recognized as risk factor for drug-induced liver injury (DILI). more

Video Of The Day : Pollution Flood in Delhi
Top News

WHO World malaria report 2018: Progress in malaria control

The number of countries nearing elimination continues to grow (46 in 2017 compared to 37 in 2010). Meanwhile in China and El Salvador, where malaria had long been endemic, no local transmission of malaria was reported in 2017, proof that intensive, country-led control efforts can succeed in reducing the risk people face from the disease... read more

Men’s health checklist: 5 things men can do for good health (WHO)

1. Have regular check-ups: Even if you feel healthy, regular health checks (such as blood pressure, blood sugar levels, prostate checks) are essential to catch any problems early and stay in good health. Mental health is just as important, and seeking help for mental health issues, including depression and anxiety, can be critical.... read more

Morning Medtalks

Morning MEDtalks with Dr KK Aggarwal 22nd November 2018

NIH statement on World COPD Day 2018 NIH-supported studies aim to reduce the burden of COPD. On November 21, World COPD Day 2018, the National Institutes of Health unites with millions of people to renew our long-standing commitment to reducing the burden of chronic obstructive pulmonary disease (COPD), a serious and debilitating... read more

Practice Updates

The first treatment specifically for patients with refractory primary hemophagocytic lymphohistiocytosis

The US Food and Drug Administration (FDA) has approved Gamifant (emapalumab-lzsg) for the treatment of pediatric (newborn and above) and adult patients with primary hemophagocytic .. read more

Persistent inflammation increases chances of adverse outcomes in post-PCI patients

Patients who have persistently high levels of inflammation following percutaneous coronary intervention (PCI) for coronary artery disease are significantly more likely to die from any cause or to have a heart attack within a year, according to a study of 7,026 patients published in .. read more

ACOG new guidelines on dysmenorrhea and endometriosis in adolescents

The American College of Obstetricians and Gynecologists (ACOG) has published a new committee opinion on dysmenorrhea and endometriosis in adolescents, online Nov. 20, 2018. Some key recommendations include:... read more

Eyes of CJD patients show evidence of prions

Researchers from the National Institutes of Health (NIH) have found evidence of prion seeding in the eyes of deceased patients of sporadic Creutzfeldt-Jakob disease (CJD). The retina consistently showed the highest seed levels; prion seeds were also present in the optic nerve,... read more

USPSTF recommends HIV PrEP for High-Risk Patients

In a draft recommendation statement published online Nov. 20, 2018 on its website, the US Preventive Services Task Force (USPSTF) recommends (“A” recommendation) that clinicians offer pre-exposure prophylaxis (PrEP) with effective antiretroviral therapy to persons who are at... read more

ESICON 2018 Updates

ADA-EASD 2018 Consensus - In Indian Context: Dr Awadhesh K Singh

  • Sulfonylureas (SUs) and thiazolidinediones (TZDs) remain the cornerstone of therapy in a developing country where the patient has to pay from his pocket.
  • Alpha-glucosidase inhibitors (AGIs) are not included in ADA-EASD consensus as they are not used in the USA, but are still useful in Indians.... read more

Adrenal Insufficiency in Children, Dr David Torpy,

  • Adrenal insufficiency refers to low plasma cortisol, often confirmed by adrenocorticotropic hormone (ACTH) stimulation testing... read more

ICS & HPA Axis Suppression: How Important is it & How should it be Managed?: Dr Kalpana Dash

  • Corticosteroids are very important in treating bronchoconstrictive lung disorders.
  • More potent ICS therapy has significant absorption across the lungs, leading to hypothalamic-pituitary-adrenal (HPA) axis suppression, iatrogenic Cushing’s syndrome, adrenal insufficiency, very rarely osteoporosis, growth failure in .. read more

Making Choices: DPP-4i, SGLT-2i or Both in Taking Next Step After Metformin: Dr JJ Mukherjee

  • Combination of DPP-4i and SGLT-2i results in greater improvement in glycemic control than each individual component alone.
  • SGLT-2i/DPP-4i vs. DPP-4i alone yields greater reductions in HbA1c and FPG... read more

Combination of Empa and Lina: A Leap Towards Holistic Diabetes Management: Dr Sujoy Majumdar

  • Empagliflozin/linagliptin fixed-dose combination (FDC) offers high efficacy with convenience of a single tablet, thereby reducing the pill burden.
  • There are 2-4 times higher odds of patients reaching the goal HbA1c compared to individual agents. It is associated with early achievement of glycemic goal with durable efficacy... read more
eMedi Humor
Medicolegal Corner
eMedi Quiz
1. Obesity.
2. Family history.
3. Use of hormone replacement therapy
4. Early menopause.
Lifestyle Updates
Inspirational Story 1: Look Fear in the Face
Inspirational Story 2: Forgive and Forget
Beware of daily items inside the house; they can worsen indoor air pollution
Stale air circulates in about 90% of air-conditioned buildings
New Delhi, 21st November 2018: Items of everyday use including room fresheners, deodorants, mosquito coils, incense sticks, wall-to-wall carpets, and office printers and photocopy machines could be worsening indoor pollution levels. This could be either as bad as the polluted air outside or even worse, indicate recent studies. It has also been found that the concentration of volatile organic compounds and PM2.5 is higher than the permissible limits even inside closed rooms in residences, corporate and government offices and multiplexes.

Improper ventilation can also cause indoor air pollution levels to peak. In more than 90% of the air-conditioned buildings, it is the stale indoor air which is circulated instead of allowing fresh outside air to come in, as it requires consumption of more energy. Outside pollution also gushes in through leakages in door and windows because of difference in air pressure.

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