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Editor-in-Chief eMediNexus – Dr KK Aggarwal
13th September 2018
Think before you prescribe
Prescribe simpler drug regimens to improve treatment adherence

Dr KK Aggarwal, Recipient of Padma Shri

Compliance to prescribed treatment is a major factor influencing the desired treatment outcome and is largely dependent on the patient. Non-compliance with the drug treatment continues to be a common problem in practice.

A systematic review of 76 studies examining the associations between dose regimens and medication compliance showed that the prescribed number of daily doses is inversely related to compliance. Adherence declined as the number of daily doses increased. Simpler, less frequent dosing regimens resulted in better compliance. Compliance was significantly higher for once-daily vs 3-times-daily, once-daily vs 4-times-daily and twice-daily vs 4-times-daily regimens (Clin Ther. 2001;23:1296-1310).

Patients were again shown to be more compliant with once-daily compared with twice-daily or thrice-daily treatment regimens in another systematic review of 20 studies. Patients receiving once-daily dosing had 22% to 41% more adherent days compared with patients receiving thrice-daily dosing; patients receiving once-daily dosing had 2% to 44% more adherent days compared with patients receiving twice-daily dosing indicating that the once-daily dose regimen had the highest adherence rates in this study (Am J Manag Care. 2009;15:e22-e33). more

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Morning Medtalks

Morning MEDTalks with Dr KK Aggarwal 13th September 2018

TEDx Video: Doctor-patient relationship:
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Practice Updates

Early language and conversation linked to language skills and IQ in school-age children

A study published online Sept. 10 in the journal Pediatrics found that children ages 18-to 24-months, who engaged in conversation and were spoken to by adults benefited during their school-age years with better language and cognition skills. Conversational turn-taking between the ages of 18-24 months accounted for 14-27% of the higher performance in IQ, verbal... read more

Positive psychological well-being can improve overall health of the heart

Maintaining positive thoughts and feelings through intervention programs can help patients achieve better overall outcomes when it comes to their cardiovascular health, according to a review paper published Sept. 10, 2018 in the Journal of the American College of Cardiology... read more

Adolescents with low aerobic fitness have more arterial stiffness

Adolescents with better aerobic fitness have more compliant arteries compared to their peers with low fitness compared to their peers who have low fitness, says a study published Sept. 11, 2018 in the European Journal of Applied Physiology. Arterial stiffness is one of the first signs of ... read more

A new formulation of GamaSTAN immune globulin as prophylaxis after exposure to hepatitis A and measles

The US Food and Drug Administration (FDA) has approved a new formulation of GamaSTAN immune globulin (human) for prophylaxis following exposure to hepatitis A virus (HAV) and for prevention or modification of measles in susceptible individuals exposed fewer ... read more

Addition of chest x-ray to WHO Four-Symptom Screening Rule improves TB detection in people living with HIV

A systematic review and meta-analysis published online August 20, 2018 in The Lancet HIV has suggested a lower sensitivity of the WHO four-symptom screening rule (absence of cough, weight loss, night sweats, or fever) among people with HIV who are on ART than in those who are ART ... read more

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Scrub typhus re-emerging in parts of India
Infection can prove fatal to life if not diagnosed and treated on time
New Delhi, 12 September 2018: About 48 cases of scrub typhus, a bacterial infection that killed 16 people and hospitalized 70 in Nagpur, have been treated in four large hospitals in Delhi since July 2018. Diagnosis of this condition is often missed as the infection mimics symptoms of common monsoon infections, such as dengue and chikungunya. The infection can be fatal if not treated on time with antibiotics, which are not prescribed for dengue and chikungunya.

Scrub typhus is mite-borne disease caused by Orientia tsutsugamushi, which was earlier called Rickettsia tsutsugamushi. It is a re-emerging zoonotic disease in India and is prevalent in many parts of India particularly in the sub-Himalayan belt, from Jammu to Nagaland. Outbreaks are frequent during the rainy season.

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