Metformin may now be safely used in patients with mild to moderate renal impairment
Dr KK Aggarwal, Recipient of Padma Shri
Metformin is the first-line oral antidiabetic drug for most patients with type 2 diabetes mellitus. Its advantages are good glycemic control; it also does not cause hypoglycaemia weight gain. Metformin is eliminated by the kidneys; hence, its use in chronic kidney disease has been restricted. Lactic acidosis has been reported with the use of metformin, which occurs when metformin accumulates in conditions of acute or progressive renal failure, acute or progressive heart failure, acute pulmonary decompensation, sepsis, dehydration. A rare side effect, but has a high case fatality rate.
Metformin was earlier indicated for use in patients with kidney disease with eGFR >60 mL/min/1.73 m2. It was contraindicated when serum creatinine level was > 1.4 mg/dL in woman and 1.5 mg/dL in men, and eGFR < 60 mL/min...... read more
You are one among the 9,88,922 allopathic doctors practising in India. You can find a clinic in every nook and corner. How do you attract patients to your practice? What do you do to become more visible to your target audience? The only solution is to be different from others and think out-of-the-box.... read more
To mark Father's Day this month, UNICEF has launched a new parenting site as part of its ‘Super Dads’ campaign recognizing fathers’ role in their children’s early development. UNICEF is calling for more support for fathers globally, including for policies that give parents the time and resources they need to spend quality time with their children. The online site will bring together fathers from across the..... read more
Dear Colleague I want to start with the most important silent epidemic of the society and that is hepatitis C, a global public health threat with significant morbidity and mortality. Being of asymptomatic nature, it is also a silent epidemic with an estimated 71 million infected globally, but only 20% diagnosed. As per WHO viral hepatitis caused 1.34 million deaths in 2015, a number comparable to deaths caused by tuberculosis and higher than those caused by HIV. ... read more
Removal of adenoids and tonsils in childhood is associated with increased long-term risk of respiratory, allergic, and infectious diseases, according to a study of almost 1.2 million children published online June 7, 2018 in JAMA Otolaryngology-Head & Neck Surgery.... read more
The US FDA has approved venetoclax for patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), with or without 17p deletion, who have received at least one prior therapy..... read more
A retrospective analysis first published May 30, 2018 in the journal Neurology concluded that restarting antiplatelet therapy in patients with spontaneous mild to moderate intracerebral hemorrhage (ICH) is not associated with worse functional outcomes or health-related quality of life at 90 days..... read more
Results of a phase III trial reported online May 24, 2018 in The Lancet Gastroenterology & Hepatology demonstrate the safety and effectiveness of elobixibat in chronic constipation. Elobixibat is a minimally absorbed inhibitor of ileal bile acid transporter..... read more
Insomnia or poor sleep with polysomnography-short sleep was associated with a 29% higher risk of incident cardiovascular disease, says a study published in the June 2018 issue of the journal Sleep.... read more
Good mental health entails balance between the sympathetic and parasympathetic systems A lot can be achieved if the stigma surrounding mental health illnesses is removed
New Delhi, 9th June 2018: The recent suicides by celebrity chef Anthony Bourdain and fashion designer Kate Spade have once again brought mental health issues to the fore. Mental health problems affect people irrespective of their age. If left undiagnosed and unmanaged for long, they can lead to a person committing suicide as well. There is a need to create awareness on the fact that understanding the warning signs and knowing who is at risk can prevent a crisis from becoming a tragedy.
India is facing a serious mental health crisis, with an estimated 56 million people suffering from depression and 38 million from anxiety disorders, according to a report by WHO. However, what exacerbates the situation is the fact that there is a lot of stigma associated with this condition.